University of Bristol invents surgical stem cell ‘glue’ for healing difficult, chronic wounds

Scientists at the University of Bristol have invented a new technology that could lead to a new generation of smart surgical glues and dressings for chronic wounds. The new method involves re-engineering the membranes of stem cells to effectively "weld" the cells together. The team modified the membrane of human mesenchymal stem cells ( hMSCs ) with thrombin, an enzyme that is involved in the wound healing process. The modified cells were placed...

Tel Aviv University prints first personalized 3D heart using patient’s own cells

Researchers at Tel Aviv University have successfully printed a partially working, vascularized 3d printed heart, starting from cells obtained from a biopsy of fatty tissues. The materials from the biopsy were separated and processed into pluripotent stem cells and an extracellular matrix containing collagens, glycoproteins, and other materials which the human heart consists of. A set of hydrogel-based inks was produced and then used to 3d print the heart. UoT's...

MTF Biologics introduces moldable cartilage allograft for cartilage lesions

MTF Biologics has introduced a new mold-able, putty-like allograft for filling in cartilage lesions called 'CartiMax'. The putty contains chondrocytes and chondrogenic growth factors, which are said to proliferate and secrete components found in hyaline cartilage ( proteoglycans and collagen type II). It is indicated for use in filling cartilage lesions in knees, ankles, and other joints; and is said to integrate into the surrounding cartilage tissue. The allograft material is...

Mallinckrodt begins phase 3 clinical trial for skin regeneration therapy

Mallinckrodt plc has reported today that they have finished enrollment for the multi-center phase 3 clinical trial of their skin regenerating therapy, Stratagraft. Current skin therapies rely on autografts, IE transplanting healthy skin from one area of the body to another. Stratagraft is a bioengineered, dual layer human skin substitute which is intended to either reduce the need for autografts, or replace them entirely in burn cases and other skin conditions.

3D printed bone takes a big step forward

Scientists at Rice University and the University of Maryland have outlined a new proof-of-concept for 3D printing artificial bone tissue, in a new paper published in Acta Biomaterialia. The artificial bone concept uses 3D printed cell scaffolds. These experimental structures are made from a custom mixture of polymer and ceramic material. The end product was designed to closely mimic the structure of bone and cartilage tissue. After the scaffolds were dried,...

Yale University and Humacyte successfully create working blood vessels from allogenic materials

Scientists and biomedical engineers at Yale University and Humacyte have created functioning human acellular vessels by taking arterial cells from cadavers, growing them into new vessels and then transforming the cells to prevent the immune system from rejecting them. After processing, what remains is the cartilage and protein structures the make up the blood vessel's structure. The artificial vessels in this study were implanted in the arms of 60 kidney disease patients. The...