GT Biopharma shows elimination of HIV infected cells using tri-specific killer engagers (TriKEs) in preclinical trial

In preclinical testing at the Masonic Cancer Center a the University of Minnesota, a series of Bi and Tri Specific killer-engager (BiKE and TriKE) constructs were tested as a means to direct natural killer cells against an HIV infected target, and were found to destroy HIV cells. BiKE and TriKE based therapies have been studied at the Masonic Cancer Center...

Arrowhead Pharmaceuticals reports advances in genetic therapies for liver disease and Hepatitis B

Arrowhead Pharmaceuticals has released a flurry of press releases related to their genetic therapy approaches. Here is a quick summary of what we have seen. Arrowhead's ARO-HBV, a third generation RNA interference therapy for Hepatitis B, presented promising results at the 2019 International Liver Congress in a Phase 1/2 clinical study. The therapy was shown to rapidly...

Pentosan Polysulfate arthritis treatment launched for dogs – humans next?

Finally, Pentosan Polysulfate is getting the attention it deserves. This drug was invented in the 1940's and has been used for interstitial cystitis, thrombi, and experimentally, Creutzfeldt–Jakob disease, and various other infectious diseases. The chondroprotective ( cartilage protecting ) aspects of this drug have been known since the 1980's, and only recently did a few pharmaceutical companies decide to take...