Bone marrow derived stem cells show a variety of positive effects in Canadian knee injection clinical trial

Results of a phase I/II clinical trial for bone marrow derived mesenchymal stromal cells ( MSCs ) were published recently in Stem Cells Translational Medicine, and validate many claims made about MSC stem cells' ability to heal damaged joints. Patients with late-stage knee osteoarthritis received a single injection of the knee of either 1, 10, or 50 million bone marrow derived MSCs, in a trial that aimed to establish safety and efficacy of the...
Chinese Academy of Sciences zoology building

Chinese scientists discover that stem cell regulator CBX4 may prove an effective target for osteoarthritis treatment

Scientists from the Institute of Biophysics of the Chinese Academy of Sciences, Peking University, and the Institute of Zoology of the Chinese Academy of Sciences have found that a protein named CBX4 acts as a regulator of mesenchymal stem cell cellular aging, and senescence. This research is a first in understanding the depth of CBX4's role in aging, and possibly identifies an avenue for treatments of osteoarthritis and other diseases related to...