University of Bristol invents surgical stem cell ‘glue’ for healing difficult, chronic wounds

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Scientists at the University of Bristol have invented a new technology that could lead to a new generation of smart surgical glues and dressings for chronic wounds. The new method involves re-engineering the membranes of stem cells to effectively “weld” the cells together.

The team modified the membrane of human mesenchymal stem cells ( hMSCs ) with thrombin, an enzyme that is involved in the wound healing process. The modified cells were placed in a solution containing the blood protein, fibrogen, and welded together through the growth of a natural hydrogel created from the cells’ surfaces. The researchers also demonstrated that the resulting structures could be use in tissue engineering.

The resulting glue is capable of turning into skin or other connective tissues, and could find use in repair of difficult to treat wounds, such as diabetic ulcers.

More more information, you can see the University of Bristol’s release here: https://www.bristol.ac.uk/news/2019/april/weld-cells.html